Process and Scale-up

In general, the work done in a laboratory cannot be simply multiplied up to an industrial scale because of the inevitable consequences of increased scale, such as a decrease in surface area and volume ratio. This may seem insignificant in the lab (for example a bit of foam), but it may be significant at industrial scale (the bit of foam has its own structure and impedes the addition of other materials).

https://www.creative-biolabs.com/drug-discovery/therapeutics/process-and-scale-up.htm