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30
DEC
2022

Toxicity and Safety Evaluation

Prior to clinical trials, it is necessary to conduct animal toxicity studies to best characterize the potential toxicity of new drug candidates. Generally, the objective of preclinical safety evaluation is to determine the toxic effects with respect to target organs, dose dependency, the relationship between clinical findings and exposure to the compound, and potential reversibility of findings. All these data will be used to provide a safe starting dosage for clinical trials and identify parameters for the clinical monitoring of potential adverse effects.

https://www.creative-biolabs.com/drug-discovery/therapeutics/animal-toxicity.htm
30
DEC
2022

Process and Scale-up

In general, the work done in a laboratory cannot be simply multiplied up to an industrial scale because of the inevitable consequences of increased scale, such as a decrease in surface area and volume ratio. This may seem insignificant in the lab (for example a bit of foam), but it may be significant at industrial scale (the bit of foam has its own structure and impedes the addition of other materials).

https://www.creative-biolabs.com/drug-discovery/therapeutics/process-and-scale-up.htm
30
DEC
2022

Pre-formulation Development

Formulation studies aim to develop a drug preparation which is both stable, safety and acceptable to the patient. Pre-formulation studies are an essential component of drug development process, and it provides the scientific basis for formulation development. It gives the physical, chemical, and mechanical properties of a new drug and helps researchers choose what ingredients (excipients) should be used in the preparation.

https://www.creative-biolabs.com/drug-discovery/therapeutics/pre-formulation-development.htm
30
DEC
2022

Formulation Development

statistically designed experiment to understand formulation parameters that impact the safety, efficiency, manufacturability, and stability in primary packaging
https://www.creative-biolabs.com/drug-discovery/therapeutics/formulation-development.htm
30
DEC
2022

Drug Abuse Liability

Drug abuse liability is the potential that a drug has properties that facilitate people becoming addicted or dependent on it. This phenomenon may be caused by drugs' pharmacological and psychopharmacological properties or social aspects around their self-administration. The addictive potency of drugs varies between different drugs. For instance, drugs such as heroin or cocaine have higher abuse liability than drugs like codeine or alcohol.https://www.creative-biolabs.com/drug-discovery/therapeutics/drug-abuse-liability.htm
21
NOV
2022

Target Localization

Custom high-quality drug target localization services for functional analysis in the process of drug discovery https://www.creative-biolabs.com/drug-discovery/therapeutics/target-localization.htm
21
NOV
2022

Metabolic Pathway Analysis for Fungi

Custom metabolic pathway analysis services for target identification and validation. https://www.creative-biolabs.com/drug-discovery/therapeutics/metabolic-pathway-analysis-for-fungi.htm
21
NOV
2022

Radioautography

Custom digital imaging services using radioautography for functional analysis of drug discovery. https://www.creative-biolabs.com/drug-discovery/therapeutics/radioautography.htm
21
NOV
2022

Atomic Force Microscopy

Custom digital imaging services using atomic force microscopy. https://www.creative-biolabs.com/drug-discovery/therapeutics/atomic-force-microscopy.htm
21
NOV
2022

Confocal Laser Scanning Microscopy

Custom digital imaging services using confocal laser scanning microscopy with the advanced drug discovery platform. https://www.creative-biolabs.com/drug-discovery/therapeutics/confocal-laser-scanning-microscopy.htm

10 episodes